| MCR Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. Belongs to the nuclear hormone receptor family. NR3 subfamily. Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of human Ortholog: 4q31.23 |
| Cellular Component: chromatin; cytosol; endoplasmic reticulum membrane; nucleoplasm; nucleus; receptor complex |
| Molecular Function: DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; estrogen response element binding; nuclear receptor activity; nuclear steroid receptor activity; protein binding; sequence-specific double-stranded DNA binding; steroid binding; zinc ion binding |
| Biological Process: intracellular steroid hormone receptor signaling pathway; positive regulation of NIK/NF-kappaB signaling; regulation of transcription by RNA polymerase II; signal transduction |
| Disease: Hypertension, Early-onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy; Pseudohypoaldosteronism, Type I, Autosomal Dominant |
| Reference #: P08235 (UniProtKB) |
| Alt. Names/Synonyms: aldosterone receptor; FLJ41052; MCR; MGC133092; Mineralocorticoid receptor; mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; MLR; MR; NR3C2; NR3C2VIT; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2; nuclear receptor subfamily 3, group C, member 2 variant 3 |
| Gene Symbols: NR3C2 |
| Molecular weight: 107,082 Da |
| Basal Isoelectric point: 7.22 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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MCR |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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