FcER1B High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family. Found on the surface of mast cells and basophils. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component:  external side of plasma membrane; Fc-epsilon receptor I complex; integral component of plasma membrane; plasma membrane
Molecular Function:  IgE binding
Biological Process:  Fc-epsilon receptor signaling pathway; immune response; inflammatory response
Disease: Ige Responsiveness, Atopic
Reference #:  Q01362 (UniProtKB)
Alt. Names/Synonyms: APY; ATOPY; beta polypeptide); Fc epsilon receptor I beta-chain; FCER1B; FCERB; FcERI; High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain); High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; immunoglobulin E receptor, high affinity, beta polypeptide; Membrane-spanning 4-domains subfamily A member 2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; MS4A1; MS4A2
Gene Symbols: MS4A2
Molecular weight: 26,534 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene