TGFBR2 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p24.1
Cellular Component:  caveola; cytosol; external side of plasma membrane; integral component of membrane; membrane raft; plasma membrane; receptor complex
Molecular Function:  ATP binding; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding
Biological Process:  activation of protein kinase activity; aging; animal organ regeneration; apoptotic process; atrioventricular valve morphogenesis; blood vessel development; brain development; branching involved in blood vessel morphogenesis; bronchus morphogenesis; cardiac left ventricle morphogenesis; common-partner SMAD protein phosphorylation; digestive tract development; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; lens development in camera-type eye; lens fiber cell apoptotic process; lung lobe morphogenesis; mammary gland morphogenesis; membranous septum morphogenesis; miRNA transport; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; outflow tract morphogenesis; outflow tract septum morphogenesis; pathway-restricted SMAD protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of skeletal muscle tissue regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to cholesterol; response to drug; response to estrogen; response to glucose; response to hypoxia; response to mechanical stimulus; response to nutrient; response to steroid hormone; secondary palate development; smoothened signaling pathway; trachea formation; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; vasculogenesis; ventricular septum morphogenesis; wound healing
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2
Reference #:  P37173 (UniProtKB)
Alt. Names/Synonyms: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TbetaR-II; TBR-ii; TBRII; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFBR2; TGFR-2; TGFR2; transforming growth factor beta receptor 2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; Transforming growth factor-beta receptor type II
Gene Symbols: TGFBR2
Molecular weight: 64,568 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein