Pim3 Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Oncoprotein; PIM family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component:  cytosol
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cell cycle; negative regulation of apoptotic process; negative regulation of insulin secretion involved in cellular response to glucose stimulus; protein phosphorylation; regulation of mitotic cell cycle
Reference #:  Q86V86 (UniProtKB)
Alt. Names/Synonyms: pim-3; pim-3 oncogene; PIM3; serine/threonine kinase Pim-3; serine/threonine protein kinase pim-3; Serine/threonine-protein kinase pim-3
Gene Symbols: PIM3
Molecular weight: 35,891 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Pim3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB