CLK1 Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 1 C1.3|1 29.09 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of RNA splicing
Reference #:  P22518 (UniProtKB)
Alt. Names/Synonyms: CDC-like kinase 1; Clk; Clk1; Dual specificity protein kinase CLK1; OTTMUSP00000024414; Protein kinase STY; Sty
Gene Symbols: Clk1
Molecular weight: 57,093 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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CLK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene