SKAR Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear speck; nucleus
Molecular Function:  nucleic acid binding; protein-containing complex binding; RNA binding
Biological Process:  mRNA export from nucleus; mRNA transport; poly(A)+ mRNA export from nucleus; positive regulation of translation; regulation of translation
Reference #:  Q8BG81 (UniProtKB)
Alt. Names/Synonyms: 1110008P04Rik; AA408269; AL022852; C77954; KIAA1649; mKIAA1649; PDI; PDIP3; PDIP46; Poldip3; polymerase (DNA-directed), delta interacting protein 3; polymerase delta interacting protein 46; Polymerase delta-interacting protein 3; S6K1 Aly/REF-like target; SKAR
Gene Symbols: Poldip3
Molecular weight: 46,132 Da
Basal Isoelectric point: 10.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene