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SKAR
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
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Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear speck; nucleus
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Molecular Function:
mRNA binding; nucleic acid binding; protein-containing complex binding; RNA binding
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Biological Process:
mRNA transport; poly(A)+ mRNA export from nucleus; positive regulation of translation; regulation of translation
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Reference #:
Q8BG81
(UniProtKB)
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Alt. Names/Synonyms: 1110008P04Rik; AA408269; AL022852; C77954; KIAA1649; mKIAA1649; PDI; PDIP3; PDIP46; Poldip3; polymerase (DNA-directed), delta interacting protein 3; polymerase delta interacting protein 46; Polymerase delta-interacting protein 3; S6K1 Aly/REF-like target; SKAR
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Gene Symbols: Poldip3
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Molecular weight:
46,132 Da
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Basal Isoelectric point:
10.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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