TGFBR1 Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.; STKR family; STKR1 subfamily; TKL group
Chromosomal Location of human Ortholog: 9q22.33
Cellular Component:  activin receptor complex; bicellular tight junction; cell surface; endosome; membrane raft; nucleus; plasma membrane; receptor complex; transforming growth factor beta ligand-receptor complex
Molecular Function:  activin binding; activin receptor activity, type I; ATP binding; growth factor binding; I-SMAD binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding
Biological Process:  activin receptor signaling pathway; angiogenesis involved in coronary vascular morphogenesis; anterior/posterior pattern specification; apoptotic process; artery morphogenesis; blastocyst development; cardiac epithelial to mesenchymal transition; cell motility; cellular response to growth factor stimulus; cellular response to transforming growth factor beta stimulus; collagen fibril organization; coronary artery morphogenesis; embryonic cranial skeleton morphogenesis; endothelial cell activation; endothelial cell migration; endothelial cell proliferation; epicardium morphogenesis; epithelial to mesenchymal transition; extracellular structure organization; filopodium assembly; germ cell migration; heart development; in utero embryonic development; intracellular signal transduction; kidney development; lens development in camera-type eye; male gonad development; mesenchymal cell differentiation; myofibroblast differentiation; negative regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; nervous system development; neuron fate commitment; parathyroid gland development; pathway-restricted SMAD protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of apoptotic signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of extracellular matrix assembly; positive regulation of filopodium assembly; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein kinase B signaling; positive regulation of SMAD protein signal transduction; positive regulation of stress fiber assembly; positive regulation of tight junction disassembly; post-embryonic development; proepicardium development; protein phosphorylation; regulation of cardiac muscle cell proliferation; regulation of cell cycle; regulation of DNA-templated transcription; regulation of epithelial to mesenchymal transition; regulation of protein binding; regulation of protein ubiquitination; response to cholesterol; roof of mouth development; signal transduction; skeletal system development; skeletal system morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis; wound healing
Disease: Loeys-dietz Syndrome 1; Multiple Self-healing Squamous Epithelioma, Susceptibility To
Reference #:  P36897 (UniProtKB)
Alt. Names/Synonyms: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; mutant transforming growth factor beta receptor I; Serine/threonine-protein kinase receptor R4; SKR4; TbetaR-I; TBR-i; TBRI; TGF-beta Receptor I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR-1; TGFR1; transforming growth factor beta receptor 1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); Transforming growth factor-beta receptor type I
Gene Symbols: TGFBR1
Molecular weight: 55,960 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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