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Claudin-5
Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 22q11.21 |
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Cellular Component:
apicolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; cortical actin cytoskeleton; lateral plasma membrane; membrane; paranode region of axon; plasma membrane; Schmidt-Lanterman incisure; tight junction
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Molecular Function:
identical protein binding; protein binding; structural molecule activity
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Biological Process:
bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; cell-cell junction assembly; establishment of blood-retinal barrier; face morphogenesis; learning; maintenance of blood-brain barrier; myelination; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of gene expression; negative regulation of vascular permeability; outflow tract morphogenesis; positive regulation of bicellular tight junction assembly; positive regulation of cell population proliferation; positive regulation of establishment of endothelial barrier; positive regulation of gene expression; positive regulation of protein binding; response to ethanol; roof of mouth development; tight junction assembly; transforming growth factor beta receptor signaling pathway
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Reference #:
O00501
(UniProtKB)
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Alt. Names/Synonyms: androgen withdrawal and apoptosis induced protein RVP1-like; AWAL; BEC1; claudin 5; Claudin-5; claudin5; CLD5; CLDN5; CPETRL1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
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Gene Symbols: CLDN5
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Molecular weight:
23,147 Da
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Basal Isoelectric point:
8.25
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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