Claudin-5 Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  apicolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; integral component of membrane; plasma membrane
Molecular Function:  identical protein binding; structural molecule activity
Biological Process:  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell-cell junction assembly; face morphogenesis; learning; outflow tract morphogenesis; positive regulation of establishment of endothelial barrier; regulation of bicellular tight junction assembly; roof of mouth development; transforming growth factor beta receptor signaling pathway
Reference #:  O00501 (UniProtKB)
Alt. Names/Synonyms: androgen withdrawal and apoptosis induced protein RVP1-like; AWAL; BEC1; claudin 5; Claudin-5; claudin5; CLD5; CLDN5; CPETRL1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Gene Symbols: CLDN5
Molecular weight: 23,147 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein