Claudin-5 Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16 A3|16 11.63 cM
Cellular Component:  apicolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; integral component of membrane; lateral plasma membrane; membrane; paranode region of axon; plasma membrane; Schmidt-Lanterman incisure
Molecular Function:  protein binding; structural molecule activity
Biological Process:  cell-cell adhesion; cell-cell junction assembly; myelination; positive regulation of establishment of endothelial barrier; transforming growth factor beta receptor signaling pathway
Reference #:  O54942 (UniProtKB)
Alt. Names/Synonyms: AI854493; Bec1; Brain endothelial cell clone 1 protein; claudin 5; Claudin-5; claudin5; CLD5; Cldn5; Lung-specific membrane protein; MBEC1; MGC102088; Tmvc; Tmvcf; transmembrane protein deleted in VCFS
Gene Symbols: Cldn5
Molecular weight: 23,054 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene