|
Claudin-5
Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 16 A3|16 11.63 cM |
|
Cellular Component:
apicolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; integral component of membrane; lateral plasma membrane; membrane; paranode region of axon; plasma membrane; Schmidt-Lanterman incisure
|
|
Molecular Function:
protein binding; structural molecule activity
|
|
Biological Process:
cell-cell adhesion; cell-cell junction assembly; myelination; positive regulation of establishment of endothelial barrier; transforming growth factor beta receptor signaling pathway
|
|
Reference #:
O54942
(UniProtKB)
|
|
Alt. Names/Synonyms: AI854493; Bec1; Brain endothelial cell clone 1 protein; claudin 5; Claudin-5; claudin5; CLD5; Cldn5; Lung-specific membrane protein; MBEC1; MGC102088; Tmvc; Tmvcf; transmembrane protein deleted in VCFS
|
|
Gene Symbols: Cldn5
|
|
Molecular weight:
23,054 Da
|
|
Basal Isoelectric point:
8.25
Predict pI for various phosphorylation states
|
