ATRIP Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Belongs to the ATRIP family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  ATR-ATRIP complex; nucleoplasm; nucleus
Molecular Function:  K63-linked polyubiquitin modification-dependent protein binding; protein binding
Biological Process:  DNA damage checkpoint signaling; DNA repair; nucleobase-containing compound metabolic process; regulation of double-strand break repair
Reference #:  Q8WXE1 (UniProtKB)
Alt. Names/Synonyms: AGS1; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; ATRIP; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740
Gene Symbols: ATRIP
Molecular weight: 85,838 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene