SRC-3 Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Belongs to the SRC/p160 nuclear receptor coactivator family. Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription factor complex
Molecular Function:  androgen receptor binding; chromatin binding; disordered domain specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen receptor binding; histone acetyltransferase activity; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; peroxisome proliferator activated receptor binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein N-terminus binding; protein-containing complex binding; RNA polymerase II complex binding; RNA polymerase II regulatory region DNA binding; RNA polymerase II transcription regulator recruiting activity; transcription coactivator activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; developmental growth; labyrinthine layer morphogenesis; mammary gland branching involved in thelarche; multicellular organism growth; negative regulation of apoptotic process; negative regulation of stem cell differentiation; positive regulation of cell growth; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of intracellular steroid hormone receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; regulation of RNA biosynthetic process; regulation of stem cell division; regulation of stem cell population maintenance; regulation of stem cell proliferation; regulation of transcription, DNA-templated; vagina development
Reference #:  O09000 (UniProtKB)
Alt. Names/Synonyms: 2010305B15Rik; ACTR; AIB-1; Aib1; Amplified in breast cancer-1 protein homolog; AW321064; bHLHe4; bHLHe42; CBP-interacting protein; KAT13; KAT13B; NCoA-3; Ncoa3; Nuclear receptor coactivator 3; p/CIP; Pcip; RAC-3; Rac3; Receptor-associated coactivator 3; SRC-3; Src3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRA; TRAM; TRAM-1; Tram1
Gene Symbols: Ncoa3
Molecular weight: 151,574 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SRC-3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA