TLE1
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Belongs to the WD repeat Groucho/TLE family. In all tissues examined, mostly in brain, liver and muscle. Note: This description may include information from UniProtKB.
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Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 9q21.32 |
Cellular Component:
beta-catenin-TCF complex; cytosol; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA-binding transcription factor binding; identical protein binding; protein binding; transcription corepressor activity
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Biological Process:
animal organ morphogenesis; negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA-templated transcription; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of Wnt signaling pathway; positive regulation of gene expression; signal transduction; Wnt signaling pathway
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Reference #:
Q04724
(UniProtKB)
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Alt. Names/Synonyms: E(Sp1) homolog; enhancer of split groucho 1; Enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; TLE family member 1, transcriptional corepressor; TLE1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 1, homolog of Drosophila E(sp1); Transducin-like enhancer protein 1
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Gene Symbols: TLE1
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Molecular weight:
83,201 Da
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Basal Isoelectric point:
6.79
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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