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PARD6A
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 8|8 D3 |
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Cellular Component:
anchoring junction; apical part of cell; apical plasma membrane; axonal growth cone; bicellular tight junction; cell cortex; cell junction; centriolar satellite; centrosome; cytoplasm; cytoskeleton; membrane; neuronal cell body; nucleus; PAR polarity complex; plasma membrane; protein-containing complex
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Molecular Function:
GTP-dependent protein binding; protein binding; small GTPase binding
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Biological Process:
cell cycle; cell division; cell-cell junction maintenance; centrosome cycle; establishment of cell polarity; establishment or maintenance of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; negative regulation of protein phosphorylation; positive regulation of protein localization to centrosome; positive regulation of protein secretion; regulation of cellular localization
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Reference #:
Q9Z101
(UniProtKB)
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Alt. Names/Synonyms: 0710008C04Rik; 2610010A15Rik; PAR-6; par-6 (partitioning defective 6,) homolog alpha; par-6 (partitioning defective 6,) homolog alpha (C. elegans); PAR-6 alpha; par-6 family cell polarity regulator alpha; PAR-6A; Par6; Par6a; PAR6alpha; Par6c; Pard6a; Partitioning defective 6 homolog alpha; Tax interaction protein 40; TAX4; TAX40; Tip-; Tip-40
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Gene Symbols: Pard6a
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Molecular weight:
37,333 Da
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Basal Isoelectric point:
8.76
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Microtubule Dynamics
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TGF-ß Signaling
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