paralemmin Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. Belongs to the paralemmin family. Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM
Cellular Component:  apicolateral plasma membrane; axon; basolateral plasma membrane; cell projection; cytoplasm; dendrite membrane; dendritic spine membrane; filopodium; filopodium membrane; intracellular membrane-bounded organelle; membrane; neuron spine; nucleus; plasma membrane; postsynaptic density
Molecular Function:  D3 dopamine receptor binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to electrical stimulus; cytoskeleton organization; negative regulation of adenylate cyclase activity; negative regulation of dopamine receptor signaling pathway; positive regulation of dendritic spine development; positive regulation of filopodium assembly; protein localization; protein localization to plasma membrane; regulation of cell shape; synapse maturation
Reference #:  Q9Z0P4 (UniProtKB)
Alt. Names/Synonyms: Palm; Paralemmin; Paralemmin-1
Gene Symbols: Palm
Molecular weight: 41,614 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene