DMAP1 Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4|4 D2.1
Cellular Component:  cytoplasm; cytosol; NuA4 histone acetyltransferase complex; nucleoplasm; nucleus; replication fork
Molecular Function:  protein binding; RNA polymerase II repressing transcription factor binding; transcription corepressor activity
Biological Process:  chromatin organization; chromatin remodeling; DNA repair; histone H2A acetylation; histone H4 acetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of protein import into nucleus; regulation of growth
Reference #:  Q9JI44 (UniProtKB)
Alt. Names/Synonyms: 1500016M21Rik; Dmap1; Dmtap1; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein-1; DNMT1-associated protein 1; DNMTAP1; MAT1-mediated transcriptional repressor; mKIAA1425; Mmtr; OTTMUSP00000008985
Gene Symbols: Dmap1
Molecular weight: 53,130 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DMAP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene