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DMAP1
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 4|4 D2.1 |
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Cellular Component:
cytoplasm; cytosol; NuA4 histone acetyltransferase complex; nucleoplasm; nucleosome; nucleus; replication fork; Swr1 complex
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Molecular Function:
protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity
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Biological Process:
chromatin organization; chromatin remodeling; DNA repair; DNA-templated transcription; histone acetylation; histone H2A acetylation; histone H4 acetylation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of protein import into nucleus; regulation of apoptotic process; regulation of cell cycle; regulation of DNA-templated transcription; regulation of double-strand break repair
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Reference #:
Q9JI44
(UniProtKB)
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Alt. Names/Synonyms: 1500016M21Rik; Dmap1; Dmtap1; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein-1; DNMT1-associated protein 1; DNMTAP1; MAT1-mediated transcriptional repressor; mKIAA1425; Mmtr; OTTMUSP00000008985
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Gene Symbols: Dmap1
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Molecular weight:
53,130 Da
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Basal Isoelectric point:
9.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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