mucolipin 1
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels. Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy. Functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily. Widely expressed in adult and fetal tissues. Note: This description may include information from UniProtKB.
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Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel |
Chromosomal Location of mouse Ortholog: 8 A1.1|8 1.92 cM |
Cellular Component:
cell projection; cytoplasmic vesicle; endosome; Golgi apparatus; intracellular membrane-bounded organelle; intracellular vesicle; late endosome; lysosomal membrane; lysosome; membrane; nucleoplasm; plasma membrane; receptor complex
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Molecular Function:
identical protein binding; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; ligand-gated calcium channel activity; lipid binding; monoatomic cation channel activity; NAADP-sensitive calcium-release channel activity; protein binding
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Biological Process:
adaptive immune response; autophagosome maturation; calcium ion export; calcium ion transmembrane transport; calcium ion transport; cellular response to calcium ion; cellular response to pH; endosomal transport; immune system process; monoatomic cation transmembrane transport; monoatomic ion transport; phagosome maturation; positive regulation of lysosome organization; protein homotetramerization; release of sequestered calcium ion into cytosol
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Reference #:
Q99J21
(UniProtKB)
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Alt. Names/Synonyms: 2210015I05Rik; MCLN1; Mcoln1; MGC7172; muco; Mucolipidin; mucolipin 1; Mucolipin-1; Transient receptor potential-mucolipin 1; TRP; TRPML1
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Gene Symbols: Mcoln1
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Molecular weight:
65,506 Da
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Basal Isoelectric point:
7.77
Predict pI for various phosphorylation states
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