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ARHGEF12
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Ubiquitously expressed. Isoform 2 is found in jejunum and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 9|9 A5.1 |
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Cellular Component:
cytoplasm; membrane
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Molecular Function:
G protein-coupled receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding
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Biological Process:
G protein-coupled receptor signaling pathway; intracellular signal transduction; regulation of blood pressure; Rho protein signal transduction
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Reference #:
Q8R4H2
(UniProtKB)
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Alt. Names/Synonyms: 2310014B11Rik; ARHGC; Arhgef12; AU019857; KIAA0380; Kiaa0382; Larg; leukemia-associated Rho guanine-nucleotide exchange factor; Leukemia-associated RhoGEF; mKIAA0382; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12
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Gene Symbols: Arhgef12
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Molecular weight:
172,349 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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