ARHGEF12 May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Ubiquitously expressed. Isoform 2 is found in jejunum and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 9|9 A5.1
Cellular Component:  cytoplasm; membrane
Molecular Function:  G protein-coupled receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  G protein-coupled receptor signaling pathway; intracellular signal transduction; regulation of Rho protein signal transduction; Rho protein signal transduction
Reference #:  Q8R4H2 (UniProtKB)
Alt. Names/Synonyms: 2310014B11Rik; ARHGC; Arhgef12; AU019857; KIAA0380; Kiaa0382; Larg; leukemia-associated Rho guanine-nucleotide exchange factor; Leukemia-associated RhoGEF; mKIAA0382; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12
Gene Symbols: Arhgef12
Molecular weight: 172,349 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below

ARHGEF12

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene