SAPS2 Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Belongs to the SAPS family. Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 15|15 E3
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus
Molecular Function:  protein phosphatase binding; protein phosphatase regulator activity
Biological Process:  regulation of phosphoprotein phosphatase activity
Reference #:  Q8R3Q2 (UniProtKB)
Alt. Names/Synonyms: 1110033O10Rik; 8430411H09Rik; B230107H12Rik; Kiaa0685; Pp6r2; Ppp6r2; protein phosphatase 6, regulatory subunit 2; SAPS domain family member 2; SAPS domain family, member 2; Saps2; Serine/threonine-protein phosphatase 6 regulatory subunit 2
Gene Symbols: Saps2
Molecular weight: 100,460 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene