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SAPS2
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Belongs to the SAPS family. Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 15|15 E3 |
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Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus
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Molecular Function:
protein phosphatase binding; protein phosphatase regulator activity
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Biological Process:
regulation of phosphoprotein phosphatase activity
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Reference #:
Q8R3Q2
(UniProtKB)
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Alt. Names/Synonyms: 1110033O10Rik; 8430411H09Rik; B230107H12Rik; Kiaa0685; Pp6r2; Ppp6r2; protein phosphatase 6, regulatory subunit 2; SAPS domain family member 2; SAPS domain family, member 2; Saps2; Serine/threonine-protein phosphatase 6 regulatory subunit 2
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Gene Symbols: Saps2
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Molecular weight:
100,460 Da
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Basal Isoelectric point:
4.7
Predict pI for various phosphorylation states
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