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FRMD4A
Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4B in epithelial polarization. May regulate MAPT secretion by activating ARF6-signaling. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 2|2 A1 |
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Cellular Component:
adherens junction; anchoring junction; bicellular tight junction; cytoplasm; cytoskeleton
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Molecular Function:
protein-macromolecule adaptor activity
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Biological Process:
establishment of epithelial cell polarity; negative regulation of protein secretion; positive regulation of protein secretion
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Reference #:
Q8BIE6
(UniProtKB)
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Alt. Names/Synonyms: 2700017I06Rik; 5330420J21; AI594879; C230040M21Rik; FERM domain containing 4A; FERM domain-containing protein 4A; FRM4A; Frmd4; Frmd4a; Gm13190; Kiaa1294; mKIAA1294; OTTMUSG00000010806; OTTMUSP00000011590
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Gene Symbols: Frmd4a
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Molecular weight:
113,879 Da
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Basal Isoelectric point:
9.02
Predict pI for various phosphorylation states
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