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USP8
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-medaited APP cleavage and amyloid-beta formation. Belongs to the peptidase C19 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of mouse Ortholog: 2|2 F1 |
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Cellular Component:
acrosomal membrane; cytoplasm; cytosol; dendritic spine; early endosome; endosome; endosome membrane; extrinsic component of plasma membrane; glutamatergic synapse; intracellular anatomical structure; membrane; midbody; nucleus; plasma membrane; postsynaptic density
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Molecular Function:
cysteine-type deubiquitinase activity; cysteine-type peptidase activity; hydrolase activity; K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; peptidase activity; protein binding; SH3 domain binding
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Biological Process:
cell cycle; cellular response to nerve growth factor stimulus; endosome organization; mitotic cytokinesis; negative regulation of lysosomal protein catabolic process; positive regulation of amyloid fibril formation; positive regulation of canonical Wnt signaling pathway; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; Ras protein signal transduction; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; regulation of protein localization; regulation of protein stability; ubiquitin-dependent protein catabolic process
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Reference #:
Q80U87
(UniProtKB)
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Alt. Names/Synonyms: AI574262; AW557536; Deubiquitinating enzyme 8; Kiaa0055; mKIAA0055; mUBPy; OTTMUSP00000016913; putative deubiquitinating enzyme; RP23-130L11.1; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; ubiquitin specific peptidase 8; ubiquitin specific protease 8; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8; Ubp; UBP8; Ubpy; Usp8
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Gene Symbols: Usp8
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Molecular weight:
122,611 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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