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XPA
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Belongs to the XPA family. Expressed in various cell lines and in skin fibroblasts. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of Human Ortholog: 4 B1|4 24.49 cM |
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Cellular Component:
cytoplasm; intercellular bridge; nucleotide-excision repair factor 1 complex; nucleus
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Molecular Function:
damaged DNA binding; DNA binding; metal ion binding; protein domain specific binding; protein homodimerization activity
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Biological Process:
base-excision repair; cellular response to DNA damage stimulus; DNA repair; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; nucleotide-excision repair; nucleotide-excision repair involved in interstrand cross-link repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA incision; protein localization to nucleus; regulation of autophagy; response to oxidative stress; response to toxic substance; response to UV; UV protection; UV-damage excision repair
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Reference #:
Q64267
(UniProtKB)
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Alt. Names/Synonyms: AI573865; DNA repair protein complementing XP-A cells homolog; OTTMUSP00000007309; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; Xpa; Xpac
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Gene Symbols: Xpa
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Molecular weight:
31,398 Da
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Basal Isoelectric point:
7.08
Predict pI for various phosphorylation states
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