XPA Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Belongs to the XPA family. Expressed in various cell lines and in skin fibroblasts. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 4 B1|4 24.49 cM
Cellular Component:  cytoplasm; intercellular bridge; nucleotide-excision repair factor 1 complex; nucleus
Molecular Function:  damaged DNA binding; DNA binding; metal ion binding; protein domain specific binding; protein homodimerization activity
Biological Process:  base-excision repair; cellular response to DNA damage stimulus; DNA repair; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; nucleotide-excision repair; nucleotide-excision repair involved in interstrand cross-link repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA incision; protein localization to nucleus; regulation of autophagy; response to oxidative stress; response to toxic substance; response to UV; UV protection; UV-damage excision repair
Reference #:  Q64267 (UniProtKB)
Alt. Names/Synonyms: AI573865; DNA repair protein complementing XP-A cells homolog; OTTMUSP00000007309; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; Xpa; Xpac
Gene Symbols: Xpa
Molecular weight: 31,398 Da
Basal Isoelectric point: 7.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene