CRMP-4 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of mouse Ortholog: 18|18 B3
Cellular Component:  cell body; cell projection; cytoplasm; cytosol; extracellular space; filamentous actin; growth cone; lamellipodium; synapse
Molecular Function:  chondroitin sulfate binding; filamin binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; phosphoprotein binding; protein binding; SH3 domain binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; negative regulation of cell migration; negative regulation of neuron projection development; nervous system development; positive regulation of filopodium assembly; positive regulation of neuron projection development; protein homooligomerization; regulation of cell migration; regulation of neuron projection development; response to axon injury
Reference #:  Q62188 (UniProtKB)
Alt. Names/Synonyms: collapsin response mediator protein 4; CRMP; CRMP-4; dihydropyrimidinase-like 3; Dihydropyrimidinase-related protein 3; DPYL3; Dpysl3; DRP-3; Drp3; TUC4; Ulip; ULIP-1; Ulip1; Unc-33-like phosphoprotein 1
Gene Symbols: Dpysl3
Molecular weight: 61,936 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene