SOX11 Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development. Expressed mainly in the nervous system, brain (fetus and adult) and hear (adult). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12|12 A2
Cellular Component:  cytoplasm; nuclear transcription factor complex; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region sequence-specific DNA binding
Biological Process:  cardiac ventricle formation; cell differentiation; closure of optic fissure; cornea development in camera-type eye; embryonic digestive tract morphogenesis; embryonic skeletal system morphogenesis; eyelid development in camera-type eye; glial cell development; glial cell proliferation; hard palate development; lens morphogenesis in camera-type eye; limb bud formation; lung morphogenesis; multicellular organism development; negative regulation of cell death; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of lymphocyte proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription regulatory region DNA binding; nervous system development; neural crest cell development; neural tube formation; neuroepithelial cell differentiation; neuron differentiation; noradrenergic neuron differentiation; outflow tract morphogenesis; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of hippo signaling; positive regulation of hormone secretion; positive regulation of lens epithelial cell proliferation; positive regulation of neurogenesis; positive regulation of neuron differentiation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; skeletal muscle cell differentiation; skeletal system development; soft palate development; somite development; spinal cord development; sympathetic nervous system development; ventricular septum morphogenesis
Reference #:  Q7M6Y2 (UniProtKB)
Alt. Names/Synonyms: 1110038H03Rik; 6230403H02Rik; AI836553; end; end1; OTTMUSP00000023364; Sox-11; Sox11; SRY (sex determining region Y)-box 11; SRY-box containing gene 11; Transcription factor SOX-11
Gene Symbols: Sox11
Molecular weight: 42,629 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene