APBA2 Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 7 C|7 34.65 cM
Cellular Component:  cytoplasm; dendritic spine; plasma membrane; Schaffer collateral - CA1 synapse; synapse; synaptic vesicle
Molecular Function:  amyloid-beta binding; identical protein binding; protein binding
Biological Process:  chemical synaptic transmission; in utero embryonic development; locomotory behavior; multicellular organism growth; protein transport; regulation of gene expression; regulation of synaptic vesicle exocytosis
Reference #:  P98084 (UniProtKB)
Alt. Names/Synonyms: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2; Amyloid beta A4 precursor protein-binding family A member 2; Amyloid-beta A4 precursor protein-binding family A member 2; Apba2; Mint 2; Mint-2; mXllL; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; OTTMUSP00000027637; X11; X11-li; X11-like; X11l; XllL
Gene Symbols: Apba2
Molecular weight: 82,758 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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APBA2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene