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NFI-B
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 4 C3|4 38.4 cM |
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Cellular Component:
cerebellar mossy fiber; fibrillar center; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription regulator inhibitor activity
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Biological Process:
anterior commissure morphogenesis; brain development; cell differentiation involved in salivary gland development; cell population proliferation; cell proliferation in forebrain; cell quiescence; chondrocyte differentiation; club cell differentiation; commissural neuron axon guidance; DNA replication; exit from mitosis; forebrain development; gene expression; generation of neurons; glandular epithelial cell differentiation; glial cell differentiation; glial cell fate specification; glial cell proliferation; hindbrain development; lung ciliated cell differentiation; lung development; negative regulation of DNA binding; negative regulation of epithelial cell proliferation involved in lung morphogenesis; negative regulation of mesenchymal cell proliferation involved in lung development; negative regulation of miRNA transcription; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neurogenesis; neuron fate specification; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; principal sensory nucleus of trigeminal nerve development; regeneration; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to bacterium; response to wounding; retina development in camera-type eye; salivary gland cavitation; stem cell population maintenance; stem cell proliferation; tissue homeostasis; type I pneumocyte differentiation; type II pneumocyte differentiation
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Reference #:
P97863
(UniProtKB)
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Alt. Names/Synonyms: 6720429L07Rik; CCAAT-box-binding transcription factor; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B; Nfib; Nuclear factor 1 B-type; Nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein
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Gene Symbols: Nfib
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Molecular weight:
63,507 Da
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Basal Isoelectric point:
8.85
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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