NFI-B Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 4 C3|4 38.4 cM
Cellular Component:  cerebellar mossy fiber; fibrillar center; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription regulator inhibitor activity
Biological Process:  anterior commissure morphogenesis; brain development; cell differentiation involved in salivary gland development; cell population proliferation; chondrocyte differentiation; club cell differentiation; commissural neuron axon guidance; DNA replication; forebrain development; glandular epithelial cell differentiation; glial cell differentiation; hindbrain development; lung ciliated cell differentiation; lung development; negative regulation of DNA binding; negative regulation of epithelial cell proliferation involved in lung morphogenesis; negative regulation of mesenchymal cell proliferation involved in lung development; negative regulation of miRNA transcription; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; principal sensory nucleus of trigeminal nerve development; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to bacterium; salivary gland cavitation; stem cell proliferation; type I pneumocyte differentiation; type II pneumocyte differentiation
Reference #:  P97863 (UniProtKB)
Alt. Names/Synonyms: 6720429L07Rik; CCAAT-box-binding transcription factor; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B; Nfib; Nuclear factor 1 B-type; Nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein
Gene Symbols: Nfib
Molecular weight: 63,507 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NFI-B

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene