CRMP-1 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Cytoskeletal; Hydrolase
Chromosomal Location of mouse Ortholog: 5 B3|5 19.96 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; cytosol; dendrite; growth cone; midbody; neuronal cell body; nucleus
Molecular Function:  filamin binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; phosphoprotein binding
Biological Process:  axon guidance; microtubule cytoskeleton organization; negative regulation of actin filament binding; negative regulation of neuron projection development; nervous system development; semaphorin-plexin signaling pathway
Reference #:  P97427 (UniProtKB)
Alt. Names/Synonyms: Collapsin response mediator protein 1; CRMP-1; Crmp1; Dihydropyrimidinase-related protein 1; DPYL1; Dpysl1; DRP; DRP-1; Inactive dihydropyrimidinase; ULIP-3; Ulip3; Unc-33-like phosphoprotein 3
Gene Symbols: Crmp1
Molecular weight: 62,168 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
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CRMP-1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein