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CRMP-1
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Cytoskeletal; Hydrolase |
| Chromosomal Location of mouse Ortholog: 5 B3|5 19.96 cM |
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Cellular Component:
actin cytoskeleton; cell projection; centrosome; cytoplasm; cytoskeleton; cytosol; dendrite; growth cone; midbody; neuronal cell body
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Molecular Function:
dihydropyrimidinase activity; filamin binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; identical protein binding; phosphoprotein binding
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Biological Process:
negative regulation of actin filament binding; negative regulation of neuron projection development; pyrimidine nucleobase catabolic process; semaphorin-plexin signaling pathway
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Reference #:
P97427
(UniProtKB)
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Alt. Names/Synonyms: Collapsin response mediator protein 1; CRMP-1; Crmp1; Dihydropyrimidinase-related protein 1; DPYL1; Dpysl1; DRP; DRP-1; Inactive dihydropyrimidinase; ULIP-3; Ulip3; Unc-33-like phosphoprotein 3
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Gene Symbols: Crmp1
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Molecular weight:
62,168 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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