p15-INK4B Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit; Tumor suppressor
Chromosomal Location of Human Ortholog: 4 C4|4 42.15 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding
Biological Process:  cell cycle; cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; cellular senescence; G2/M transition of mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of cell cycle G1/S phase transition; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of glial cell proliferation; negative regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; spleen development
Reference #:  P55271 (UniProtKB)
Alt. Names/Synonyms: AV083695; Cdkn2b; CDN2B; cyclin dependent kinase inhibitor 2B; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; INK4b; MTS; MTS2; p14-INK4b; p15; p15(INK4b); p15-INK4b; p15IN; p15INK4b
Gene Symbols: Cdkn2b
Molecular weight: 13,789 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene