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p15-INK4B
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 4 C4|4 42.15 cM |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding
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Biological Process:
cell cycle; cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; cellular senescence; G2/M transition of mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of cell cycle G1/S phase transition; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of glial cell proliferation; negative regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; spleen development
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Reference #:
P55271
(UniProtKB)
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Alt. Names/Synonyms: AV083695; Cdkn2b; CDN2B; cyclin dependent kinase inhibitor 2B; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; INK4b; MTS; MTS2; p14-INK4b; p15; p15(INK4b); p15-INK4b; p15IN; p15INK4b
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Gene Symbols: Cdkn2b
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Molecular weight:
13,789 Da
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Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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