MKK4 dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 17p12
Cellular Component:  axon; cytosol; dendrite cytoplasm; nucleus; perikaryon
Molecular Function:  ATP binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase activity; protein tyrosine kinase activity
Biological Process:  apoptotic process; cell growth involved in cardiac muscle cell development; cellular response to mechanical stimulus; cellular response to sorbitol; Fc-epsilon receptor signaling pathway; JNK cascade; negative regulation of motor neuron apoptotic process; peptidyl-tyrosine phosphorylation; positive regulation of DNA replication; positive regulation of neuron apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell apoptotic process; response to wounding; signal transduction
Reference #:  P45985 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK activating kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK1; MAP kinase kinase 4; MAP2K4; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; mitogen-activated protein kinase kinase 4; MKK4; MP2K4; PRKMK4; SAPK/ERK kinase 1; SEK1; SERK1
Gene Symbols: MAP2K4
Molecular weight: 44,288 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene