KIF3A Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 11 B1.3|11 31.97 cM
Cellular Component:  axon cytoplasm; axoneme; cell projection; centriole; centrosome; cilium; cytoplasm; cytoskeleton; kinesin complex; kinesin II complex; microtubule; microtubule cytoskeleton; motile cilium; neuron projection; neuronal cell body; photoreceptor connecting cilium
Molecular Function:  ATP binding; ATPase activity; intraciliary transport particle B binding; kinesin binding; microtubule binding; microtubule motor activity; nucleotide binding; protein binding; protein phosphatase binding; protein-containing complex binding; Rab GTPase binding; spectrin binding
Biological Process:  anterior/posterior pattern specification; anterograde axonal transport; axon guidance; cell projection organization; centriole-centriole cohesion; cilium assembly; dentate gyrus development; determination of left/right symmetry; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; epidermal stem cell homeostasis; epidermis development; heart development; heart looping; in utero embryonic development; inner ear receptor cell stereocilium organization; kidney development; microtubule anchoring at centrosome; microtubule-based movement; motile cilium assembly; neural precursor cell proliferation; neural tube development; non-motile cilium assembly; positive regulation of axo-dendritic protein transport; positive regulation of epithelial cell proliferation; positive regulation of establishment or maintenance of cell polarity regulating cell shape; positive regulation of intracellular protein transport; positive regulation of receptor-mediated endocytosis; protein localization to cell junction; protein transport; smoothened signaling pathway
Reference #:  P28741 (UniProtKB)
Alt. Names/Synonyms: 111-11-71; 111-11-86; AW124694; DNA sequence AF180004; DNA sequence AF180009; Kif; Kif3; Kif3a; Kifl; kinesin family member 3A; kinesin family-like; kinesin-II subunit; Kinesin-like protein KIF3A; Kns3; Microtubule plus end-directed kinesin motor 3A; N-4 kinesin; RP23-188H3.1
Gene Symbols: Kif3a
Molecular weight: 80,170 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene