NAP1L1 Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 10 D1|10 58.67 cM
Cellular Component:  cytoplasm; neuron projection; nucleus
Molecular Function:  kinase binding; protein binding
Biological Process:  nervous system development; nucleosome assembly; positive regulation of neural precursor cell proliferation; positive regulation of neurogenesis
Reference #:  P28656 (UniProtKB)
Alt. Names/Synonyms: AA407126; AI256722; Brain protein DN38; D10Ertd68; D10Ertd68e; NAP-1; NAP-1-related protein; Nap1l1; NP1L1; Nrp; Nucleosome assembly protein 1-like 1; nucleosome assembly protein-1
Gene Symbols: Nap1l1
Molecular weight: 45,345 Da
Basal Isoelectric point: 4.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene