STX7 May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Belongs to the syntaxin family. Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of mouse Ortholog: 10|10 A4
Cellular Component:  azurophil granule; early endosome; endocytic vesicle; endomembrane system; endosome; immunological synapse; late endosome; late endosome membrane; lysosomal membrane; lysosome; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; SNARE complex; synaptic vesicle; synaptic vesicle membrane; tertiary granule; vesicle
Molecular Function:  chloride channel inhibitor activity; protein binding; protein-containing complex binding; SNAP receptor activity; SNARE binding; syntaxin binding
Biological Process:  endosome to lysosome transport; intracellular protein transport; organelle assembly; organelle localization; positive regulation of receptor localization to synapse; positive regulation of T cell mediated cytotoxicity; regulation of protein localization to plasma membrane; vesicle docking; vesicle fusion; vesicle-mediated transport
Reference #:  O70439 (UniProtKB)
Alt. Names/Synonyms: AI315064; AI317144; AW107239; Stx7; Syn7; syntaxin 7; Syntaxin-7
Gene Symbols: Stx7
Molecular weight: 29,821 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein