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P38G
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Highly expressed in skeletal muscle and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; EC 2.7.11.24; Kinase, protein; MAPK family; MAPK/p38 subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); p38 subfamily |
| Chromosomal Location of human Ortholog: 22q13.33 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
ATP binding; magnesium ion binding; MAP kinase activity; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
cell cycle; intracellular signal transduction; MAPK cascade; muscle organ development; myoblast differentiation; negative regulation of cell cycle; peptidyl-serine phosphorylation; positive regulation of muscle cell differentiation; positive regulation of peptidase activity; regulation of cell cycle; signal transduction; signal transduction in response to DNA damage
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Reference #:
P53778
(UniProtKB)
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Alt. Names/Synonyms: ERK-6; ERK3; ERK6; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; MAPK12; Mitogen-activated protein kinase 12; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MK12; P38G; P38GAMMA; PRKM12; SAPK-3; SAPK3; Stress-activated protein kinase 3
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Gene Symbols: MAPK12
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Molecular weight:
41,940 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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B Cell Receptor Signaling
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NF-kB Signaling
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Phospholipase Signaling
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Regulation of P38 MAPKs
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-Like Receptor Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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