CTNND2 Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Belongs to the beta-catenin family. Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15|15 B2
Cellular Component:  cell junction; cell projection; cell-cell adherens junction; cell-cell junction; cytoplasm; neuron projection; nucleus; perikaryon; plasma membrane; postsynaptic density
Molecular Function:  beta-catenin binding; cadherin binding
Biological Process:  cell adhesion; cell-cell adhesion; cell-cell junction assembly; dendritic spine morphogenesis; learning; morphogenesis of a branching structure; multicellular organism development; regulation of canonical Wnt signaling pathway; regulation of synaptic plasticity; synapse organization
Reference #:  O35927 (UniProtKB)
Alt. Names/Synonyms: catenin (cadherin associated protein), delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); catenin delta 2; Catenin delta-2; Catn; Catnd2; CTND2; Ctnnd2; Neural plakophilin-related ARM-repeat protein; neuro; neurojugin; Neurojungin; NPRAP
Gene Symbols: Ctnnd2
Molecular weight: 135,000 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene