PSMD4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. Belongs to the proteasome subunit S5A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  cytosol; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex
Molecular Function:  identical protein binding; molecular adaptor activity; polyubiquitin modification-dependent protein binding
Biological Process:  proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  O35226 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Af1; ang; angiocidin; anti secretory factor 1; Mcb1; Multiubiquitin chain-binding protein; multiubiquitin-chain-binding protein; OTTMUSP00000021246; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Psmd4; rpn10; RPN10 homolog
Gene Symbols: Psmd4
Molecular weight: 40,704 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene