NPL4 The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I. Belongs to the NPL4 family. Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; nucleus; UFD1-NPL4 complex; VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function:  ATPase binding; metal ion binding; protein-containing complex binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  Golgi organization; negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; retrograde protein transport, ER to cytosol; ubiquitin-dependent protein catabolic process
Reference #:  P60670 (UniProtKB)
Alt. Names/Synonyms: AK129375; KIAA1499; mKIAA1499; Npl4; NPL4 homolog, ubiquitin recognition factor; Nploc4; nuclear protein localization 4 homolog; nuclear protein localization 4 homolog (S. cerevisiae); Nuclear protein localization protein 4 homolog; OTTMUSP00000004608; Protein NPL4
Gene Symbols: Nploc4
Molecular weight: 68,017 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NPL4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene