ITSN1 Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Calcium-binding; GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 16|16 C4
Cellular Component:  apical dendrite; calyx of Held; cell junction; cell projection; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; dendritic spine; endocytic vesicle; endosome; glutamatergic synapse; intracellular vesicle; lamellipodium; membrane; neuron projection; neuronal cell body; nuclear envelope; nucleus; plasma membrane; postsynaptic actin cytoskeleton; presynaptic endocytic zone; synapse
Molecular Function:  calcium ion binding; guanyl-nucleotide exchange factor activity; kinase activator activity; metal ion binding; molecular adaptor activity; proline-rich region binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  cellular protein localization; endocytosis; exocytosis; intracellular signal transduction; negative regulation of neuron apoptotic process; positive regulation of caveolin-mediated endocytosis; positive regulation of dendritic spine development; positive regulation of growth hormone secretion; positive regulation of protein kinase B signaling; protein transport; regulation of modification of postsynaptic actin cytoskeleton; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; synaptic vesicle endocytosis
Reference #:  Q9Z0R4 (UniProtKB)
Alt. Names/Synonyms: AA517634; AA545208; AI316805; AI839402; AI848451; EH and SH3 domains protein 1; Eh domain, SH3 domain regulator of endocytosis 1; Ehsh1; Ese1; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin short form 2 variant 2; Intersectin-1; intersectin-L; Itsn; Itsn1; OTTMUSP00000023652; Sh3p17
Gene Symbols: Itsn1
Molecular weight: 194,297 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene