PKAR1A Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of mouse Ortholog: 11 E1|11 72.33 cM
Cellular Component:  axoneme; cAMP-dependent protein kinase complex; centrosome; cytoplasm; cytosol; glutamatergic synapse; immunological synapse; membrane; multivesicular body; neuromuscular junction; nucleotide-activated protein kinase complex; plasma membrane; plasma membrane raft; protein-containing complex; sperm connecting piece; synapse
Molecular Function:  cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; ubiquitin protein ligase binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; animal organ morphogenesis; cardiac muscle cell proliferation; cellular response to glucagon stimulus; heart development; mesenchymal cell proliferation; mesoderm formation; negative regulation of activated T cell proliferation; negative regulation of cAMP-dependent protein kinase activity; negative regulation of gene expression; negative regulation of protein kinase activity; positive regulation of insulin secretion; protein phosphorylation; regulation of protein kinase activity; sarcomere organization
Reference #:  Q9DBC7 (UniProtKB)
Alt. Names/Synonyms: 1300018C22Rik; cAMP-dependent protein kinase type I-alpha regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; KAP0; OTTMUSP00000003353; OTTMUSP00000003354; PKAR1A; Prkar1a; protein kinase, cAMP dependent regulatory, type 1, alpha; protein kinase, cAMP dependent regulatory, type I, alpha; RIalpha; Tse; Tse-; Tse-1; Tse1
Gene Symbols: Prkar1a
Molecular weight: 43,185 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein