TERF2IP Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Belongs to the RAP1 family. Ubiquitous. Highly expressed. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  chromosome; chromosome, telomeric region; cytoplasm; cytosol; nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; shelterin complex
Molecular Function:  DNA binding; G-rich strand telomeric DNA binding; phosphatase binding; protein binding; telomeric DNA binding
Biological Process:  negative regulation of DNA recombination at telomere; negative regulation of protein phosphorylation; negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein acetylation; protein localization to chromosome, telomeric region; regulation of double-strand break repair via homologous recombination; regulation of telomere maintenance; regulation of transcription, DNA-templated; telomere maintenance; telomere maintenance via telomere lengthening
Reference #:  Q91VL8 (UniProtKB)
Alt. Names/Synonyms: Rap1; RAP1 homolog; Repressor/activator protein 1 homolog; TE2IP; telomeric repeat binding factor 2, interacting protein; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; Terf2ip; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein Rap1
Gene Symbols: Terf2ip
Molecular weight: 43,353 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene