PAK4 a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding; transferase activity
Biological Process:  activation of protein kinase activity; apoptotic process; cell cycle; cell migration; cellular response to organic cyclic compound; dendritic spine development; negative regulation of endothelial cell apoptotic process; phosphorylation; positive regulation of angiogenesis; protein phosphorylation; regulation of MAPK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q8BTW9 (UniProtKB)
Alt. Names/Synonyms: 5730488L07Rik; AW555722; Kiaa1142; mKIAA1142; OTTMUSP00000030258; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; PAK-4; Pak4; Serine/threonine-protein kinase PAK 4
Gene Symbols: Pak4
Molecular weight: 64,623 Da
Basal Isoelectric point: 9.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene