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CDC23
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC8/CDC23 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 18 B1|18 18.69 cM |
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Cellular Component:
anaphase-promoting complex; cytoplasm
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Biological Process:
anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic metaphase plate congression; positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; protein ubiquitination; regulation of mitotic metaphase/anaphase transition
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Reference #:
Q8BGZ4
(UniProtKB)
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Alt. Names/Synonyms: 6030435O18; Anapc8; Anaphase-promoting complex subunit 8; APC8; Cdc23; CDC23 (cell division cycle 23, yeast, homolog); CDC23 cell division cycle 23; Cell division cycle protein 23 homolog; Cyclosome subunit 8; D18Ertd243; D18Ertd243e
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Gene Symbols: Cdc23
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Molecular weight:
68,562 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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