CDC23 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC8/CDC23 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of mouse Ortholog: 18 B1|18 18.69 cM
Cellular Component:  anaphase-promoting complex; cytoplasm
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic metaphase plate congression; positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; protein ubiquitination; regulation of mitotic metaphase/anaphase transition
Reference #:  Q8BGZ4 (UniProtKB)
Alt. Names/Synonyms: 6030435O18; Anapc8; Anaphase-promoting complex subunit 8; APC8; Cdc23; CDC23 (cell division cycle 23, yeast, homolog); CDC23 cell division cycle 23; Cell division cycle protein 23 homolog; Cyclosome subunit 8; D18Ertd243; D18Ertd243e
Gene Symbols: Cdc23
Molecular weight: 68,562 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
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CDC23

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene