SAFB2 Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA-binding
Chromosomal Location of Human Ortholog: 17|17 D
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus
Molecular Function:  DNA binding; identical protein binding; nucleic acid binding; RNA binding; sequence-specific DNA binding
Biological Process:  regulation of androgen receptor signaling pathway; regulation of mRNA processing; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; Sertoli cell differentiation
Reference #:  Q80YR5 (UniProtKB)
Alt. Names/Synonyms: AA389433; AI255170; mKIAA0138; SAF-B2; Safb2; Scaffold attachment factor B2
Gene Symbols: Safb2
Molecular weight: 111,838 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein