HUWE1 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1. Belongs to the UPL family. TOM1/PTR1 subfamily. Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: X|X F3
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  base-excision repair; cell differentiation; cellular response to DNA damage stimulus; circadian regulation of gene expression; DNA repair; histone ubiquitination; positive regulation of protein ubiquitination; protein monoubiquitination; protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q7TMY8 (UniProtKB)
Alt. Names/Synonyms: 5430439H10Rik; AU041296; C430014N20Rik; C80292; E3 ubiquitin-protein ligase HUWE1; E3Histone; Gm1718; HECT, UBA and WWE domain containing 1; HECT, UBA and WWE domain-containing protein 1; Huwe1; Ib772; Kiaa0312; LASU1; Mcl-1 ubiquitin ligase; Mule; OTTMUSP00000020882; upstream regulatory element binding protein 1; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; Ureb1
Gene Symbols: Huwe1
Molecular weight: 482,635 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein