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snRNP 70
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 7 B3|7 29.28 cM |
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Cellular Component:
nuclear speck; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex; U1 snRNP; U2-type prespliceosome
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Molecular Function:
mRNA binding; nucleic acid binding; RNA binding; U1 snRNA binding; U1 snRNP binding
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Biological Process:
mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; regulation of RNA splicing
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Reference #:
Q62376
(UniProtKB)
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Alt. Names/Synonyms: 2700022N21Rik; 3200002N22Rik; 70kDa; AI325098; R74807; Rnu; Rnu1p70; Rnulp70; RU17; small nuclear ribonucleoprotein 70 (U1); small nuclear ribonucleoprotein 70kDa (U1); snRNP 70; Snrnp70; Snrp70; Srnp70; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein 70 kDa polypeptide A; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U1-70; U1-70K
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Gene Symbols: Snrnp70
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Molecular weight:
51,992 Da
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Basal Isoelectric point:
9.94
Predict pI for various phosphorylation states
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