snRNP 70 Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 7 B3|7 29.28 cM
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U1 snRNP
Molecular Function:  mRNA binding; nucleic acid binding; RNA binding; U1 snRNA binding; U1 snRNP binding
Biological Process:  mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; regulation of RNA splicing
Reference #:  Q62376 (UniProtKB)
Alt. Names/Synonyms: 2700022N21Rik; 3200002N22Rik; 70kDa; AI325098; R74807; Rnulp70; RU17; small nuclear ribonucleoprotein 70 (U1); small nuclear ribonucleoprotein 70kDa (U1); Snrnp70; Snrp70; Srnp70; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein 70 kDa polypeptide A; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U1-70; U1-70K
Gene Symbols: Snrnp70
Molecular weight: 51,992 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
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snRNP 70

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene