NFI-A Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4 C6|4 45.52 cM
Cellular Component:  cell junction; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  DNA replication; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; synapse maturation; ureter development
Reference #:  Q02780 (UniProtKB)
Alt. Names/Synonyms: 1110047K16Rik; 9430022M17Rik; CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NF1A; NFI-A; Nfia; Nuclear factor 1 A-type; Nuclear factor 1/A; Nuclear factor I/A; OTTMUSP00000008283; TGGCA-binding protein
Gene Symbols: Nfia
Molecular weight: 58,553 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene