HDGF
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. Belongs to the HDGF family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytokine; Transcription regulation |
Chromosomal Location of mouse Ortholog: 3 F1|3 38.78 cM |
Cellular Component:
cytoplasm; extracellular region; extracellular space; nucleoplasm; nucleus; transcription repressor complex
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Molecular Function:
actin binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; growth factor activity; heparin binding; nucleotide binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription corepressor activity; transcription corepressor binding; tubulin binding
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Biological Process:
cellular response to interleukin-7; chromatin remodeling; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein localization to nucleus
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Reference #:
P51859
(UniProtKB)
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Alt. Names/Synonyms: AI118077; D3Ertd299; D3Ertd299e; HDGF; heparin binding growth factor; Hepatoma-derived growth factor; Tdrm1
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Gene Symbols: Hdgf
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Molecular weight:
26,269 Da
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Basal Isoelectric point:
4.8
Predict pI for various phosphorylation states
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