RDBP Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Belongs to the RRM NELF-E family. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17 B1|17 18.4 cM
Cellular Component:  NELF complex; nuclear body; nucleoplasm; nucleus; plasma membrane
Molecular Function:  nucleic acid binding; protein binding; RNA binding
Biological Process:  negative regulation of mRNA polyadenylation; negative regulation of transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated
Reference #:  P19426 (UniProtKB)
Alt. Names/Synonyms: D17h6s45; negative elongation factor complex member E, Rdbp; Negative elongation factor E; NELF; NELF-E; Nelfe; Rd; RD RNA-binding protein; Rdbp; RNA-binding protein RD
Gene Symbols: Rdbp
Molecular weight: 42,554 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene