RSK3 Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily; Translation; Tumor suppressor
Chromosomal Location of human Ortholog: 6q27
Cellular Component:  cytoplasm; cytosol; meiotic spindle; nucleoplasm; nucleus; synapse
Molecular Function:  ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity
Biological Process:  brain renin-angiotensin system; cardiac muscle cell apoptotic process; cellular response to carbohydrate stimulus; chemical synaptic transmission; heart contraction; heart development; intracellular signal transduction; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of meiotic nuclear division; oocyte maturation; peptidyl-serine phosphorylation; positive regulation of apoptotic process; positive regulation of gene expression; regulation of protein processing; signal transduction
Reference #:  Q15349 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 2; HU-2; KS6A2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90-RSK3; p90RSK2; pp90RSK3; ribosomal protein S6 kinase A2; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RPS6KA2; RSK; RSK-3; RSK3; S6K-alpha; S6K-alpha-2; S6K-alpha2
Gene Symbols: RPS6KA2
Molecular weight: 83,239 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein