DOCK1 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q26.2
Cellular Component:  cytoplasm; cytosol; guanyl-nucleotide exchange factor complex; membrane; nuclear speck; nucleus
Molecular Function:  GTPase activator activity; protein binding; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process:  apoptotic process; blood coagulation; cell migration; cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; integrin-mediated signaling pathway; phagocytosis, engulfment; positive regulation of epithelial cell migration; positive regulation of GTPase activity; positive regulation of substrate adhesion-dependent cell spreading; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q14185 (UniProtKB)
Alt. Names/Synonyms: 180 kDa protein downstream of CRK; ced5; dedicator of cyto-kinesis 1; dedicator of cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK1; DOCK180; DOwnstream of CrK
Gene Symbols: DOCK1
Molecular weight: 215,346 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DOCK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein