CRF-R1 iso2 G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Belongs to the G-protein coupled receptor 2 family. Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  endosome; integral component of membrane; integral component of plasma membrane; intrinsic component of plasma membrane; plasma membrane
Molecular Function:  corticotrophin-releasing factor receptor activity; protein binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cellular response to corticotropin-releasing hormone stimulus; corticotropin secretion; female pregnancy; G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; immune response; negative regulation of voltage-gated calcium channel activity; parturition; regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway; regulation of corticosterone secretion
Reference #:  P34998-2 (UniProtKB)
Alt. Names/Synonyms: corticotropin releasing hormone receptor 1; Corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1; CRHR1f; CRHR1L
Gene Symbols: CRHR1
Molecular weight: 47,671 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
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CRF-R1 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein