NDRG1 Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. Belongs to the NDRG family. Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Vesicle
Chromosomal Location of mouse Ortholog: 15|15 D2
Cellular Component:  adherens junction; centrosome; cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; membrane; microtubule; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane
Molecular Function:  cadherin binding; gamma-tubulin binding; microtubule binding; small GTPase binding
Biological Process:  mast cell activation; negative regulation of cell population proliferation; peripheral nervous system myelin maintenance; postsynapse organization; regulation of cell population proliferation; signal transduction
Reference #:  Q62433 (UniProtKB)
Alt. Names/Synonyms: CAP; CAP43; CMT4D; DRG; DRG1; HMSNL; N-myc downstream regulated 1; N-myc downstream regulated gene 1; N-myc downstream regulated-like; N-myc downstream-regulated gene 1 protein; Ndr1; Ndrg1; Ndrl; NMSL; PRO; Protein Ndr1; Protein NDRG1; PROXY1; RTP; Tdd5
Gene Symbols: Ndrg1
Molecular weight: 43,009 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene